Synthesis and In Vitro Biological Evaluation of Aminonaphthoquinones and Benzo[b]phenazine-6,11-dione Derivatives as Potential Antibacterial and Antifungal Compounds

Table 1

In vitro antibacterial and antifungal activity of the synthesized compounds.

Microorganisms	MIC values (g/mL)
	3a	3b	3c	3d	3e	3f	3g	3h	4a	4b	4c	Reference antimicrobials
Fungi
C. albicans	—	—	—	78.12	—	—	78.12	—	—	—	—	4.9 (Clotrimazole)
Gram-positive bacteria
S. aureus	—	—	1250	312.5	—	625	312.5	—	1250	1250	1250	1.2 (Cefuroxime-Na)
S. epidermidis	1250	1250	1250	312.5	—	1250	312.5	1250	—	1250	156.2	9.8 (Cefuroxime)
E. faecalis	312.5	1250	1250	625	1250	1250	312.5	1250	1250	1250	1250	128 (Amikacin)
Gram-negative bacteria
P. aeruginosa	1250	1250	1250	1250	625	1250	1250	1250	1250	—	1250	2.4 (Ceftazidime)
E. coli	—	—	—	—	—	—	625	—	—	—	—	4.9 (Cefuroxime-Na)
K. pneumoniae	—	—	—	1250	1250	—	1250	—	—	—	1250	4.9 (Cefuroxime-Na)
P. mirabilis	—	—	1250	1250	—	—	1250	—	—	—	—	2.4 (Cefuroxime-Na)