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Journal of Chemistry
Volume 2015, Article ID 803867, 6 pages
Research Article

Synthesis and Evaluation of Antimicrobial Activity of Nitrones from Derivatives of Aryl-Substituted Dihydroisoquinoline

1Laboratory of Chemistry of Natural Products, Faculty of Science, Sfax University, BP 1171, 3000 Sfax, Tunisia
2Laboratory of Plant Biotechnology Applied to Crop Improvement, Faculty of Science, Sfax University, BP 1171, 3000 Sfax, Tunisia
3Higher Institute of Biotechnology, Sfax University, BP 1172, 3000 Sfax, Tunisia

Received 16 February 2015; Revised 25 May 2015; Accepted 25 May 2015

Academic Editor: Andrea Penoni

Copyright © 2015 Mouna Bouzid et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This paper describes the synthesis of a series of dihydroisoquinoline nitrones by isomerization of the corresponding oxaziridines. Nitrones 4a–c were obtained in excellent yields and high purity by a simple and effective method from the isomerization of oxaziridines. The synthesized compounds were also evaluated for their antibacterial activity against Gram-positive and Gram-negative bacteria and fungus.