Baicalin and Baicalein Inhibit Src Tyrosine Kinase and Production of IL-6

<div>Inhibition values of IL-6 production in LPS-stimulated THP-1 cells for the flavonoid compounds baicalin and baicalein. Full inhibitory activity of the level of IL-6 could be observed for baicalein for the three highest tested concentrations (1000, 333, and 111 <i>μ</i>g/mL, which would give IC<sub>50</sub> value of 88 <i>μ</i>g/mL, or 326 <i>μ</i>M), whereas baicalin inhibited IL-6 production only at a highest tested concentration (1000 <i>μ</i>g/mL, which would give IC<sub>50</sub> value of 578 <i>μ</i>g/mL, or 1295 <i>μ</i>M).</div>

Journal of Chemistry

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Figure 3: Baicalin and Baicalein Inhibit Src Tyrosine Kinase and Production of IL-6 