Core Cross-linked Star Polymers for Temperature/pH Controlled Delivery of 5-Fluorouracil

Table 2

Preparation of linear block copolymer arms.

Entries	Polymer	M : CTA : I	(target); (g/mol)	(GPC); (g/mol)	Ð; ()	Yield (wt%)
1	PolyNIPAAm-b-polyHA	22 : 1 : 0.2	11,645	12,780	1.065	70
2	PolyNIPAAm-b-polyHA	32 : 1 : 0.2	15,820	17,890	1.175	70
3	PolyNIPAAm-b-polyHA	50 : 1 : 0.2	19,930	20,200	1.137	72
4	PolyNIPAAm-b-polyHA	32 : 1 : 0.2	31,111	32,070	1.177	75
5	Poly(NIPAAm-co-4MBA9%)-b-polyHA	32 : 1 : 0.2	21,160	21,730	1.030	71
6	Poly(NIPAAm-co-4MBA9%)-b-polyHA	64 : 1 : 0.2	25,160	25,340	1.011	65
7	Poly(NIPAAm-co-4MBA5%)-b-polyHA	32 : 1 : 0.2	27,200	28,570	1.038	60

Reactions in p-dioxane at 70°C for 16 h, M = HA; macro-CTA is PNIPAAm ( = 8,208 g/mol); macro-CTA is PNIPAAm ( = 10,820 g/mol); macro-CTA is PNIPAAm ( = 14,430 g/mol); macro-CTA is PNIPAAm ( = 26,110 g/mol); macro-CTA is P(NIPAAm-co-4MBA_9%) ( = 15,160 g/mol); macro-CTA is P(NIPAAm-co-4MBA_9%) ( = 15,160 g/mol); macro-CTA is P(NIPAAm-co-4MBA_5%) ( = 22,000 g/mol); .