Research Article
Synthesis and Anticancer Activity of 1-(1H-Indol-3-yl)-2-(4-diarylmethylpiperazine-1-yl)ethane-1,2-dione Derivatives
Table 1
Antiproliferative activities (IC50) of compounds 19–30 against human cancer cell lines.
| Compd. | Cell lines (IC50, μM) | Hela | A-549 | ECA-109 |
| 19 | 6.75 ± 0.40 | 11.29 ± 1.60 | 16.65 ± 1.98 | 20 | 4.06 ± 0.06 | 14.74 ± 2.68 | 8.23 ± 1.46 | 21 | 7.22 ± 1.72 | 16.72 ± 1.56 | 9.51 ± 1.22 | 22 | 11.58 ± 1.05 | 12.92 ± 1.17 | 12.26 ± 0.99 | 23 | 4.78 ± 0.67 | 13.34 ± 2.05 | 2.13 ± 0.35 | 24 | 15.03 ± 2.01 | 33.28 ± 4.35 | 8.74 ± 1.22 | 25 | 8.99 ± 1.21 | 20.00 ± 2.05 | 8.19 ± 0.75 | 26 | 5.21 ± 0.70 | 70.89 ± 5.33 | 2.60 ± 0.36 | 27 | 93.17 ± 5.00 | 97.42 ± 9.21 | 12.80 ± 1.98 | 28 | >212 | 74.56 ± 8.73 | 153.35 ± 14.36 | 29 | 61.12 ± 6.85 | 28.19 ± 2.26 | 162.90 ± 11.78 | 30 | >194 | >194 | >194 | DDP | 17.50 ± 0.83 | 30.89 ± 1.44 | 12.73 ± 0.70 |
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Values presented are means of three experiments.
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