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Journal of Chemistry
Volume 2016, Article ID 5286462, 7 pages
Research Article

A Synthetic Approach to Pyrazolopyranopyrimidinones and Pyrazolopyranooxazinones as Antimicrobial Agents

1Department of Chemistry, Faculty of Science, Ain Shams University, Abbassia, Cairo 11566, Egypt
2Department of Chemistry, Faculty of Engineering, Ain Shams University, Abbassia, Cairo 11566, Egypt
3Department of Microbial Chemistry, National Research Centre, 33 El Bohouth St. (Former Tahrir St.), Dokki, Cairo 12622, Egypt

Received 12 July 2016; Accepted 6 September 2016

Academic Editor: Mohamed Afzal Pasha

Copyright © 2016 A. K. Elziaty et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The hitherto unknown 6-amino-4-(2-chloro-5-nitrophenyl)-3-methyl-1,4-dihydropyrano[2,3-c] pyrazole-5-carbonitrile 1a was synthesized. Both 1a and its 2,4 dichlorophenyl derivative 1b were utilized as building blocks for the preparation of novel class of pyrazolopyrano-[oxazines 2ad and pyrimidinones 3ad]. Synthesis of these compounds was achieved by two alternative acylation steps followed by ammonolysis. The structures of the synthesized compounds were elucidated by spectral data and elemental analysis. Screening and evaluation of these products as antimicrobial agents showed that the derivatives 1b, 2s, 3b, and 3d possess a potent activity.