Synthesis and Biological Evaluation of Novel Piperazine Containing Hydrazone Derivatives

Table 1

Some properties of the compounds (3a–k).

Compound	R	R′	Yield (%)	Mp (°C)	Molecular formula	Molecular weight
3a	H	F	74	181	C19H20FN5O3	385
3b	H	OCH3	80	207	C20H23N5O4	397
3c	H	OH	70	262	C19H21N5O4	383
3d	H	OC2H5	76	204	C21H25N5O4	411
3e	Cl	Cl	72	165	C19H19Cl2N5O3	436
3f	H	CN	78	226	C20H20N6O3	392
3g	H	CF3	82	212	C20H20F3N5O3	435
3h	H	N(CH3)2	75	95	C21H26N6O3	410
3i	H	N(C2H5)2	78	221	C23H30N6O3	438.5
3j	H	CH3	73	227	C20H23N5O3	381
3k	H	SCH3	81	203	C20H23N5O3S	413.5