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Journal of Chemistry
Volume 2016 (2016), Article ID 7317015, 8 pages
http://dx.doi.org/10.1155/2016/7317015
Research Article

Synthesis, Characterization, and Antimicrobial Activities of Coordination Compounds of Aspartic Acid

1Department of Chemistry, Obafemi Awolowo University, Ife Central, Ile-Ife 220282, Osun State, Nigeria
2Department of Chemistry NWU, Mafikeng Campus, Private Bag X2046, Mmabatho 2735, South Africa
3Department of Pharmaceutics, Obafemi Awolowo University, Ife Central, Ile-Ife 220282, Osun State, Nigeria

Received 1 September 2015; Accepted 27 October 2015

Academic Editor: Nigam P. Rath

Copyright © 2016 T. O. Aiyelabola et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Coordination compounds of aspartic acid were synthesized in basic and acidic media, with metal ligand M : L stoichiometric ratio 1 : 2. The complexes were characterized using infrared, electronic and magnetic susceptibility measurements, and mass spectrometry. Antimicrobial activity of the compounds was determined against three Gram-positive and three Gram-negative bacteria and one fungus. The results obtained indicated that the availability of donor atoms used for coordination was a function of the pH of the solution in which the reaction was carried out. This resulted in varying geometrical structures for the complexes. The compounds exhibited a broad spectrum of activity and in some cases better activity than the standard.