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Journal of Chemistry
Volume 2016 (2016), Article ID 7508724, 7 pages
http://dx.doi.org/10.1155/2016/7508724
Research Article

Novel Palladium(II) and Platinum(II) Complexes with a Fluoropiperazinyl Based Ligand Exhibiting High Cytotoxicity and Anticancer Activity In Vitro

1Department of Chemistry, Hashemite University, P.O. Box 150459, Zarqa 13115, Jordan
2Department of Chemistry and Earth Sciences, College of Arts and Sciences, Qatar University, P.O. Box 2713, Doha, Qatar
3Department of Physiology and Biochemistry, The University of Jordan, Amman 11942, Jordan
4Department of Biology and Biotechnology, Hashemite University, Zarqa 13115, Jordan

Received 10 December 2015; Accepted 31 January 2016

Academic Editor: Josefina Pons

Copyright © 2016 Kayed A. Abu-Safieh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

cis-Dichloro-palladium(II) and cis-dichloro-platinum(II) complexes (2, 4) of the general formula [M(N-N)Cl2] (M=Pd(II) and Pt(II), N-N= 1,2-diamino-4-fluoro-5-(4-methyl-1-piperazinyl) benzene, (DFMPB)) and the dicationic palladium(II) complex [Pd(N-N)(CH3CN)2](BF4)2 (3) have been prepared and characterized by elemental analysis, 1H-NMR-, mass spectroscopy, and IR spectroscopy. The cytotoxic effect of these complexes against MDA-231 and MCF-7 human breast cancer cell lines and K562 human leukemia cell line has been studied. The influence was dose dependent and varies with cell type. The palladium(II) complex (2) showed superior cytotoxic effect compared with the corresponding platinum(II) complex and the standard, cisplatin, when tested against all the above cell lines.