Determination of Cefoperazone Sodium in Presence of Related Impurities by Improved Classical Least Squares Chemometric Methods: A Comparative Study

Table 3

Analysis results for the prediction of test set of CEF and its impurities by the proposed chemometric models.

Test set	⁢CLS		⁢SRACLS		⁢NAP-CLS		⁢OSC-CLS		⁢DOSC-CLS
Taken (μg mL^−1)	Found (μg mL^−1)		Found (μg mL^−1)		Found (μg mL^−1)		Found (μg mL^−1)		Found (μg mL^−1)
25	27.23	108.94	25.94	103.76	25.87	102.16	25.40	101.60	25.40	101.60
19	20.58	108.29	19.33	101.74	19.72	100.16	19.01	100.05	19.01	100.05
22	24.16	109.83	22.77	103.50	22.88	101.82	22.30	101.36	22.30	101.36
21	23.18	110.4	21.76	103.62	21.81	102.00	21.35	101.67	21.35	101.67
23	25.61	111.33	24.05	104.57	23.94	102.61	23.45	101.96	23.45	101.96
25	27.92	111.66	26.25	105.00	25.64	103.08	25.58	102.32	25.57	102.28
19	21.08	110.95	19.55	102.89	19.59	101.42	19.24	101.26	19.24	101.26
22	24.54	111.54	22.84	103.82	22.73	102.28	22.37	101.68	22.37	101.68
21	23.76	113.13	22.04	104.95	21.93	103.10	21.54	102.57	21.54	102.57
Mean%		110.67		103.76		102.07		101.61		101.60
SD		1.49		1.03		0.91		0.72		0.72
RMSEP		2.37		1.03		0.51		0.39		0.39