Determination of Cefoperazone Sodium in Presence of Related Impurities by Improved Classical Least Squares Chemometric Methods: A Comparative Study

Table 4

Statistical comparison of the results obtained by the proposed methods and the reported HPLC method for determination of CEF in pharmaceutical formulation (Cefobid® Vial).

Parameter	SRACLS	NAP-CLS	OSC-CLS	DOSC-CLS	Reported HPLC
Mean	102.96	104.18	104.93	104.97	102.85
SD	1.74	0.74	1.96	1.96	1.42
Variance	3.01	0.55	3.83	3.82	2.03
	6	6	6	6	6
Student’s -test (2.228)	0.119	2.017	2.097	2.145	—
-test (5.050)	1.485	3.673	1.889	1.889	—

Reference official method is HPLC [9].