Design Synthesis and Biological Evaluation of Novel N-Nitro Acid Amide Derivatives as Lead Compounds of Herbicide

Table 1

The structure and physical data summary of all target compounds.

Number	R1,2,3	R′	Yield/%
I-1	2,4,6-tri-Cl	Phenyl	45
I-2	2,4,6-tri-Br	-CH3	42
Number	R1,2,3	R′′	Yield/%
II-1	2,4,6-tri-F	Phenyl	59
II-2	2,4,6-tri-F	4-OCH3Ph	63
II-3	2,4,6-tri-F	4-ClPh	51
II-4	2,4,6-tri-F	2,4-di-ClPh	49
II-5	2,4,6-tri-F	3-NO3Ph	45
II-6	2,4,6-tri-F	3-ClPh	43
II-7	2,4,6-tri-F	2-FPh	53
II-8	2,4,6-tri-F	4-CH3Ph	49
II-9	2,4,6-tri-F	Thienyl	55
II-10	2,4,6-tri-Cl	Phenyl	57
II-11	2,4,6-tri-Cl	2,4-di-ClPh	62
II-12	2,4,6-tri-Cl	3-NO3Ph	70
II-13	2,4,6-tri-Cl	3-ClPh	67
II-14	2,4,6-tri-Cl	2-FPh	44
II-15	2,4,6-tri-Cl	4-CH3Ph	73
II-16	2,4,6-tri-Cl	Thienyl	56
II-17	2,4,6-tri-Br	Phenyl	53
II-18	2,4,6-tri-Br	4-OCH3Ph	71
II-19	2,4,6-tri-Br	3-NO2Ph	65
II-20	2,4,6-tri-Br	3-ClPh	41
II-21	2,4,6-tri-Br	2-FPh	57
II-22	2,4,6-tri-Br	Thienyl	50