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Journal of Chemistry
Volume 2016, Article ID 9315614, 9 pages
Research Article

(+)-CSA Catalyzed Multicomponent Synthesis of 1-[(1,3-Thiazol-2-ylamino)methyl]-2-naphthols and Their Ring-Closure Reaction under Ultrasonic Irradiation

1Department of Chemistry, Faculty of Art and Sciences, Kirklareli University, Kayali Campus, 39100 Kırklareli, Turkey
2Department of Chemistry, Faculty of Art and Sciences, Yildiz Technical University, Davutpaşa Campus, 34210 Istanbul, Turkey

Received 12 February 2016; Accepted 29 March 2016

Academic Editor: Rajeev Sakhuja

Copyright © 2016 Emel Pelit and Zuhal Turgut. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


New 1-[(1,3-thiazol-2-ylamino)methyl]-2-naphthols were obtained by condensation of 2-aminothiazole, aromatic aldehydes, and 2-naphthol in the presence of (+)-camphor-10-sulfonic acid ((+)-CSA) as an effective catalyst under ultrasound-promoted solvent-free conditions. The 1-[(1,3-thiazol-2-ylamino)methyl]-2-naphthol derivatives were converted in ring-closure reaction with formaldehyde to the corresponding naphthoxazine derivatives.