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Journal of Chemistry
Volume 2016, Article ID 9804162, 12 pages
http://dx.doi.org/10.1155/2016/9804162
Research Article

Chemical Speciation of the System Cu(II)-Indomethacin in Ethanol and Water by UV-Vis Spectrophotometry

1Laboratorio de Fisicoquímica Analítica, Unidad de Investigación Multidisciplinaria, Facultad de Estudios Superiores-Cuautitlán, Universidad Nacional Autónoma de México, Carretera Cuautitlán-Teoloyucan Km 2.5, San Sebastián Xhala, 54714 Cuautitlán Izcalli, MEX, Mexico
2Laboratorio R-105/R-107, Área de Química Analítica, Departamento de Química, División de Ciencias Básicas e Ingeniería, Universidad Autónoma Metropolitana-Iztapalapa, Avenida San Rafael Atlixco 186, Colonia Vicentina, 09340 México, DF, Mexico

Received 11 December 2015; Accepted 1 March 2016

Academic Editor: Narcis Avarvari

Copyright © 2016 Norma Rodríguez-Laguna et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

It has been proposed that the metal-drug complexes could be in fact the active agents displaying therapeutic effects of drugs. The characterization of the global formation equilibrium of complexes formed between metal ions and species with biological activity such as nonsteroidal anti-inflammatory drugs provides essential information to understand the mechanism of action of drugs. Since equilibrium constants determine the relative predominance of species, they provide crucial information to identify what complexes are more likely to be present in the system being responsible for the therapeutic effects of the drug. In this paper, the systems formed between copper and Indomethacin of different concentrations in ethanol or water were studied by UV-Vis spectrophotometry. The stoichiometry of the complexes Cu(II)–Indomethacin and their formation constants were investigated. Moreover, molecular structures of the Cu(II)–Indomethacin complexes were explored by means of the molecular modeling within the frame of the density functional theory.