Synthesis and In Vitro AMPK Activation of Cycloalkyl/Alkarylbiguanides with Robust In Vivo Antihyperglycemic Action

Figure 3

AMPK phosphorylation by compounds 4–6. The analogues 4 and 5 are able to activate the enzyme in a similar way to metformin, whereas the analogue 6 appears to induce AMPK phosphorylation in a larger extent. , , and .