Research Article
Synthesis and Experimental Validation of New PDI Inhibitors with Antiproliferative Activity
Table 2
Cytotoxicity of the synthesized compounds against a panel of human cancer cell lines.
| | Compound | IC50 (μM) | | MCF-7 | MDA-MB 231 | U87G | OVCAR-8 | Mia PaCa-2 | HCT116 p53+/+ | SKOV3 WT |
| | 1 | >50 | >50 | >50 | nt | nt | nt | nt | | 2 | >50 | >50 | >50 | nt | nt | nt | nt | | 3 | >50 | >50 | >50 | nt | nt | nt | nt | | 4 | >50 | >50 | >50 | nt | nt | nt | nt | | 5 | >50 | 42.4 ± 0.6 | 45.1 ± 0.9 | nt | nt | nt | nt | | 6 | >50 | >50 | >50 | nt | nt | nt | nt | | 7 | >50 | >50 | >50 | nt | nt | nt | nt | | 8 | 5.8 ± 0.2 | 8.7 ± 0.1 | 8.5 ± 0.3 | 3.4 ± 0.4 | 5.0 ± 0.3 | 11.1 ± 0.5 | 29.2 ± 0.5 | | 9 | 6.1 ± 0.4 | 9.7 ± 0.3 | 8.8 ± 0.3 | 3.8 ± 0.6 | 5.1 ± 0.2 | 13.3 ± 0.6 | 28.1 ± 0.2 | | 10 | 7.9 ± 0.9 | 9.7 ± 0.3 | 18.3 ± 0.8 | 6.9 ± 0.9 | 7.0 ± 0.9 | 19.3 ± 0.6 | 40.9 ± 0.6 |
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Each value represents the average of three independent experiments ± SD.
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