New Caffeic Acid Phenylethyl Ester Analogs Bearing Substituted Triazole: Synthesis and Structure-Activity Relationship Study towards 5-Lipoxygenase Inhibition

Scheme 1

Synthesis of series 1: (i): propargyl bromide, Na₂CO₃, KI, HMPA, 0°C-rt, overnight, 43%; (ii): appropriate aryl bromide (7a–c), NaN₃, DMSO, rt, overnight; (iii): 6, CuSO₄5H₂O, sodium ascorbate, H₂O, rt, overnight (8a: 42%; 8b: 57%; 8c: 53%).