Synthesis and Biological Evaluation of Novel Jatrorrhizine Derivatives with Amino Groups Linked at the 3-Position as Inhibitors of Acetylcholinesterase

Table 1

In vitro inhibition IC₅₀ (µM) and selectivity of jatrorrhizine derivatives for AChE and BuChE.

Compounds	IC50 (µM)		Selectivity for
	Jatrorrhizine			>100	>115
Tacrine			0.23
3a		>100	>216
3b		>100	>260
3c		>100	>310
3d		>100	>243
3e		>100	>338
3f		>100	>121
3g		>100	>300

% inhibitory concentration (means ± SEM of three experiments) of AChE from electric eel; % inhibitory concentration (means ± SEM of three experiments) of BuChE from equine serum; for AChE = IC₅₀ (BuChE)/IC₅₀ (AChE).