Table 2: In vivo studies of DM based on BV.

Venom sourceAnimal modelDurationDoseOutcomesYear, reference

BV from Sigma, MO, USAMice25 weeks0.5 mg/kg(i) Inhibited insulitis
(ii) Inhibited onset and cumulative incidence of diabetes
1999 [20]
Iranian Honey BV (Apis mellifera)Lewis rats4 months0.5 mg/kg(i) Increased serum insulin level
(ii) Decreased serum triglyceride contents
(iii) Decreased serum total cholesterol
2012 [21]
Apis cerana BVHuman30 minutesApis cerana bees () sting the groups individually(i) Decreased blood sugar
(ii) Decreased blood cholesterol
(iii) Decreased blood triglyceride contents
(iv) Increased eosinophil count
2014 [22]
Mongolian BV (Apis mellifera)Rabbits14 daysA bee sting (contains 0.2–0.5 mL of BV)(i) Decreased blood glucose levels
(ii) Decreased blood cholesterol levels
(iii) Decreased low density lipoproteins
(iv) Increased high density lipoproteins
2015 [23]