Synthesis of Ibuprofen Conjugated Molecular Transporter Capable of Enhanced Brain Penetration

Figure 3

Distribution tests in mouse tissues (left column: control, middle: (8), and right: (9)). Fluorescence micrographs of ((a)–(c)) brain, ((d)–(f)) heart, ((g)–(i)) lung, ((j)–(l)) kidney, ((m)–(o)) spleen, and ((p)–(r)) liver tissue sections, isolated from mice 20 min after ip injection. Exposure times (ms); brain: 5000, heart: 1000, lung: 5000, kidney: 2000, spleen: 2000, and liver: 2000. = 488 nm (green fluorescence from FITC).