Synthesis of Ibuprofen Conjugated Molecular Transporter Capable of Enhanced Brain Penetration

Scheme 1

(a) Glycine ethylester⋅HCl, EDC, DMAP, DMF, and Et₃N, rt, 24 h, 99%; (b) LiOH and THF-H₂O (5 : 1), rt, 36 h, 60%.