Research Article
A Stability-Indicating RP-HPLC-UV Method for Determination and Chemical Hydrolysis Study of a Novel Naproxen Prodrug
Table 2
Results of forced degradation stability studies.
| Stress condition | Nature of pro-NP | Number of determinations | Time (hours) | Temperature (°C) | Degradation (%) |
| Hydrolysis, acidic | Solution | In 0.1 N HCl | 24 | 25 | 21.5 |
| Hydrolysis, alkali | Solution | In 0.1 N NaOH | 0 | 25 | 100 | In 0.01 N NaOH | 0 | 25 | 100 |
| Oxidation | Solution | In 3% H2O2 | 24 | 25 | 0 | In 3% H2O2 | 24 | 50 | 0 | In 6% H2O2 | 2 | 50 | 0 |
| Thermal | Solid | Once | 48 | 70 | 0 |
| Photolytic | Solid | Once | 48 | 25 | 0 |
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