A Stability-Indicating RP-HPLC-UV Method for Determination and Chemical Hydrolysis Study of a Novel Naproxen Prodrug

Table 7

The results from the hydrolysis kinetics.

Time (hours)	pH 7.4		SGF		pH 5.5
	[]	log [A]	[A]	log [A]	[A]	log [A]
0	14.498	1.161308	15.912	1.201725	15.658	1.194736
0.5	14.223	1.152991	15.601	1.193152	15.586	1.192735
1	14.134	1.150265	15.41	1.187803	15.223	1.1825
2	13.895	1.142859	14.423	1.159056	15.409	1.187774
3	13.872	1.142139	13.975	1.145352	15.542	1.191507
4	13.697	1.136625	13.53	1.131298	15.171	1.181014
5	13.712	1.137101	13.052	1.115677	15.315	1.185117
6	14.099	1.149188	13.04	1.115278	15.367	1.186589
7	13.966	1.145072	12.88	1.109916	15.754	1.197391
8	14.208	1.152533	12.675	1.102948	15.998	1.204066

is for pro-NP.