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Journal of Chemistry
Volume 2017, Article ID 5385843, 6 pages
Research Article

An Efficient Synthesis of Milnacipran Hydrochloride via Reductive Amination of Aldehyde

1Nifty Labs Pvt. Ltd., Hyderabad 500016, India
2Sri Venkateswara University, Tirupathi 517502, India
3Texas A&M University, College Station, TX 77843, USA

Correspondence should be addressed to Ram Reddy; moc.liamg@r6002.mar

Received 14 November 2016; Revised 31 January 2017; Accepted 27 February 2017; Published 20 March 2017

Academic Editor: Mohamed Afzal Pasha

Copyright © 2017 Neha Reddy Desireddy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


An efficient synthesis of milnacipran hydrochloride has been accomplished. The important application of this paper is the reductive amination of aldehyde to primary amine with water soluble reagents. This method provides a high yield of primary amine as the major product, reduces the number of steps, and discourages by-products.