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Journal of Chemistry
/
2017
/
Article
/
Tab 3
/
Research Article
An Efficient Synthesis of Milnacipran Hydrochloride via Reductive Amination of Aldehyde
Table 3
pH of the reaction mixture.
Entry
Additive
pH
Ratio
(
1
:
5
)
Yield %
1
AcOH
7
1 : 1
40
2
Aq. NH
3
(5 eq)
8
4 : 1
50
3
Aq. NH
3
(10 eq)
10
10 : 1
65
4
Aq. NH
3
(40 eq)
12
20 : 1
75
a: ratios calculated based on TLC profile.