An Efficient Synthesis of Milnacipran Hydrochloride via Reductive Amination of Aldehyde

Table 3

pH of the reaction mixture.

Entry	Additive	pH	Ratio (1 : 5)	Yield %
1	AcOH	7	1 : 1	40
2	Aq. NH3 (5 eq)	8	4 : 1	50
3	Aq. NH3 (10 eq)	10	10 : 1	65
4	Aq. NH3 (40 eq)	12	20 : 1	75

a: ratios calculated based on TLC profile.