An Efficient Synthesis of Milnacipran Hydrochloride via Reductive Amination of Aldehyde

<table class="table-group" id="tab4"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td class="align_left">Entry </td><td class="align_center">Ethanol mL</td><td class="align_center">Temp °C</td><td class="align_center">Yield%</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td class="align_left">1</td><td class="align_center">20</td><td class="align_center">RT</td><td class="align_center">No rxn</td></tr><tr><td class="align_left">2</td><td class="align_center">20</td><td class="align_center">40</td><td class="align_center">25</td></tr><tr><td class="align_left">3</td><td class="align_center">20</td><td class="align_center">55</td><td class="align_center">57</td></tr><tr><td class="align_left">4</td><td class="align_center">20</td><td class="align_center">75</td><td class="align_center">75</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Reductive amination reaction temperature.

Journal of Chemistry

tab4

Table 4

Table 4: An Efficient Synthesis of Milnacipran Hydrochloride via Reductive Amination of Aldehyde 