An Efficient Synthesis of Milnacipran Hydrochloride via Reductive Amination of Aldehyde

Table 5

NaCNBH₃ mole eq optimization.

Entry	NaCNBH3 eq	Temp °C	Yield%
1	0.5	75	28
2	1	75	45
3	2	75	55
4	3	75	75