An Efficient Synthesis of Milnacipran Hydrochloride via Reductive Amination of Aldehyde

<table class="table-group" id="tab6"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td class="align_left">Entry </td><td class="align_center">Reagent</td><td class="align_center">Temp °C</td><td class="align_center">Rxn time (h)</td><td class="align_center">Yield%</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td class="align_left">1</td><td class="align_center">NaCNBH<sub>3</sub></td><td class="align_center">75</td><td class="align_center">1</td><td class="align_center">28</td></tr><tr><td class="align_left">2</td><td class="align_center">NaCNBH<sub>3</sub></td><td class="align_center">75</td><td class="align_center">2</td><td class="align_center">45</td></tr><tr><td class="align_left">3</td><td class="align_center">NaCNBH<sub>3</sub></td><td class="align_center">75</td><td class="align_center">4</td><td class="align_center">55</td></tr><tr><td class="align_left">4</td><td class="align_center">NaCNBH<sub>3</sub></td><td class="align_center">75</td><td class="align_center">6</td><td class="align_center">75</td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Journal of Chemistry

tab6

Table 6

Table 6: An Efficient Synthesis of Milnacipran Hydrochloride via Reductive Amination of Aldehyde 