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Journal of Chemistry
Volume 2017, Article ID 5610707, 6 pages
Research Article

Enaminonitrile as Building Block in Heterocyclic Synthesis: Synthesis of Novel 4H-Furo[2,3-d][1,3]oxazin-4-one and Furo[2,3-d]pyrimidin-4(3H)-one Derivatives

Chemistry Department, Faculty of Science, Ain Shams University, Abbasia, Cairo 11566, Egypt

Correspondence should be addressed to Manal M. El-Shahawi; moc.oohay@13iwahahsle

Received 24 January 2017; Accepted 28 March 2017; Published 20 April 2017

Academic Editor: Xinyong Liu

Copyright © 2017 Manal M. El-Shahawi and Ahmed K. El-Ziaty. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


2-Amino-4,5-diphenylfuran-3-carbonitrile 1 was utilized as building block for the construction of new furo[2,3-d]pyrimidin-4(3H)-one derivative 2 and 4H-furo2,3-d1,3oxazin-4-one derivative 3 via treatment with acetic anhydride and benzoyl chloride, respectively. The 4H-furo2,3-d1,3oxazin-4-one derivative 3 was transformed into novel furo[2,3-d]pyrimidin-4(3H)-ones 48, tetrazolylfuran derivative 10, and furo[3,2-d]imadazolone derivative 11 via reaction with various nitrogen nucleophiles. The structure features of the synthesized compounds were established from their spectral and elemental analyses.