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Journal of Chemistry
Volume 2017 (2017), Article ID 6080129, 5 pages
Research Article

Structure-Activity Relationships of N-Cinnamoyl and Hydroxycinnamoyl Amides on α-Glucosidase Inhibition

1Faculty of Mathematics and Natural Sciences, South-West University “Neofit Rilski”, 66 Ivan Mihailov Str., 2700 Blagoevgrad, Bulgaria
2REQUIMTE-UCIBIO, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre s/n, 4169-007 Porto, Portugal
3Faculty of Science, Section of Chemistry, Charles University, Hlavova 2030/8, 12843 Prague 2, Czech Republic
4Faculty of Education, Department of Chemistry, Janos Selye University, Bratislavská Cesta 3322, 94501 Komárno, Slovakia

Correspondence should be addressed to Maya G. Chochkova

Received 6 March 2017; Revised 21 May 2017; Accepted 6 June 2017; Published 11 July 2017

Academic Editor: Albert Demonceau

Copyright © 2017 Maya G. Chochkova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Currently, there is an increasing interest towards -glucosidase inhibition of various diseases including diabetes mellitus type 2, cancer, HIV, and B- and C-type viral hepatitis. Cinnamic acid derivatives have been shown to be potentially valuable as a new group of -glucosidase inhibitors. Therefore, herein, the -glucosidase inhibitory activity of trans-N-cinnamoyl and hydroxycinnamoyl amides was studied in vitro. Results revealed that the tested hydroxycinnamoyl amides (116) inhibited a-glucosidase with IC50s ranging between 0.76 and 355.1 μg/ml. Compounds 1, 2, 5, 6, 9, 14, and 15 showed significant inhibition of yeast -glucosidase, being even more potent ones than the used positive inhibitor acarbose (μg/ml).