Research Article

Nitrate and Nitrite Promote Formation of Tobacco-Specific Nitrosamines via Nitrogen Oxides Intermediates during Postcured Storage under Warm Temperature

Figure 1

Proposed formation pathways of the major TSNAs found in cured tobacco leaves. Nitrosating agents can directly interact with nornicotine, anatabine, and anabasine to form NNN, NAT, and NAB, respectively. Nicotine is less susceptible to nitrosation; thus NNK is produced from pseudo-oxynicotine, an oxidized derivative of nicotine.