A Novel Green Synthesis of Thalidomide and Analogs

Table 1

Comparison of thalidomide synthesis using DMAP/NH₄Cl, NH₄OAc, and thiourea in the monomode microwave at 150°C for 10 minutes.

Reagent	Phthalimide	Thalidomide
Thiourea	59%	40%
DMAP NH4Cl	57%	43%
Ammonium acetate	90%	7%