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Journal of Chemistry
Volume 2017, Article ID 6924601, 12 pages
https://doi.org/10.1155/2017/6924601
Research Article

Ranitidine Loaded Biopolymer Floats: Designing, Characterization, and Evaluation

Department of Chemistry, University of Sargodha, Sargodha 40100, Pakistan

Correspondence should be addressed to Muhammad Ashraf Shaheen; kp.ude.sou@neehahsam

Received 17 June 2017; Revised 28 September 2017; Accepted 11 October 2017; Published 14 December 2017

Academic Editor: Somdet Srichairatanakool

Copyright © 2017 Abdul Karim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The float formulation is a strategy to improve the bioavailability of drugs by gastroretentive drug delivery system (GRDDS). A drug delivery model based on swellable and reswellable low density biopolymers has been designed to evaluate its drug release profile using ranitidine (RNT) as a model drug and formulations have been prepared utilizing 32 factorial designs. The drug release (DR) data has been subjected to various kinetic models to investigate the DR mechanism. A reduction in rate has been observed by expanding the amounts of PSG and LSG parts, while an expansion has been noted by increasing the concentration of tragacanth (TG) and citric acid (CA) with an increment in floating time. The stearic acid (SA) has been used to decrease the lag time because a decrease in density of system was observed. The kinetic analysis showed that the optimized formulation (S4F3) followed zero-order kinetics and power law was found to be best fitted due to its minimum lag time and maximum floating ability. The resemblance of observed and predicted values indicated the validity of derived equations for evaluating the effect of independent variables while kinetic study demonstrated that the applied models are feasible for evaluating and developing float for RNT.