Synthesis and Antitumor Activity of Novel Pyridoxine-Based Bioisosteric Analogs of trans-Stilbenes

Figure 1

The natural ER agonist estradiol (I), examples of ER targeting drugs (II–IV), and compounds studied in this work (V); highlighted is the trans-diarylethylene motif characteristic of the bioisosteric analogs of the natural agonist.