Synthesis and Antitumor Activity of Novel Pyridoxine-Based Bioisosteric Analogs of trans-Stilbenes

Table 1

Results of the cytotoxicity screening experiment against two cell lines.

	Cytotoxicity, IC50 µM		Selectivity index,
	HEK-293	MCF-7
4a	2.7 ± 0.3	81.2 ± 6.5	0.03
4b	22.8 ± 2.4	1.9 ± 0.9	12.0
4c	>293.0	7.9 ± 4.9	37.0
5b	23.1 ± 2.3	32.4 ± 2.6	0.7
6a	36.1 ± 0.1	67.8 ± 1.0	0.5
6b	>306.0	>306.0	1.0
6c	>320.0	>320.0	1.0
Doxorubicin	1.2 ± 0.1	1.2 ± 0.1	1.0