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Journal of Chemistry
Volume 2017, Article ID 8418930, 8 pages
Research Article

Synthesis of New (E)-2-(1H-Indole-3-ylcarbonyl)-3-heteroaryl-acrylonitriles via Microwave-Assisted Knoevenagel Condensation

Organic Synthesis Laboratory and Biological Activity (LSO-Act-Bio), Institute of Chemistry of Natural Resources, Universidad de Talca, Talca, Chile

Correspondence should be addressed to Margarita I. Gutiérrez; lc.aclatu@zerreitugm

Received 8 March 2017; Revised 2 May 2017; Accepted 11 May 2017; Published 11 June 2017

Academic Editor: Andrea Trabocchi

Copyright © 2017 Adriana V. Treuer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Given the broad spectrum of biological uses of heteroaryl-acrylonitrile derivatives, it is necessary to find simple methods to synthesize and diversify this family of compounds. We report a stereoselective synthesis of a series of new (E)-2-(1H-indole-3-ylcarbonyl)-3-heteroaryl-acrylonitriles (3a3i) obtained from 3-(cyanoacetyl)indole and heteroaryl-aldehydes under microwave-assisted Knoevenagel reaction at 300 W of potency and 100°C. The desired derivatives (3a3i) were obtained with variable yields (30–94%) and time reactions (8–90 min). All the heteroaryl-acrylonitriles were characterized by physicoanalytical techniques such IR, 1H, 13C NMR, and electrospray mass spectrometry.