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Journal of Chemistry
Volume 2017, Article ID 8418939, 10 pages
Research Article

Palladium on Layered Double Hydroxide: A Heterogeneous System for the Enol Phosphate Carbon-Oxygen Bond Activation in Aqueous Media

1Instituto de Química, Universidade do Estado do Rio de Janeiro, 20550-900 Rio de Janeiro, RJ, Brazil
2Instituto de Química, Universidade Federal do Rio de Janeiro, 21941-903 Rio de Janeiro, RJ, Brazil
3Instituto de Pesquisas de Produtos Naturais Walter B. Mors, Universidade Federal do Rio de Janeiro, 21941-614 Rio de Janeiro, RJ, Brazil

Correspondence should be addressed to Jaqueline D. Senra; moc.liamg@arnesdj and Luiz Fernando B. Malta; rb.jrfu.qi@atlambfl

Received 7 September 2016; Accepted 23 October 2016; Published 3 January 2017

Academic Editor: Bartolo Gabriele

Copyright © 2017 Jaqueline D. Senra et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In this work, a new catalytic approach for the C-O activation of enol phosphates based on a palladium supported on layered double hydroxide was developed. In this case, two different ketene aminal phosphates were used as models to study the synthesis of α-phenyl enecarbamates N-Boc/CBz under the Suzuki-Miyaura conditions. The use of an ortho-bromoaniline as precursor allowed the synthesis of the 2-phenyl indole through an arylation/Heck cyclization. Catalyst reusability enabled the synthesis of the heterocycle in moderate yields for four consecutive runs.