Synthesis, Molecular Docking Studies, and Antifungal Activity Evaluation of New Benzimidazole-Triazoles as Potential Lanosterol 14α-Demethylase Inhibitors

Table 1

MIC₅₀ (µg/mL) values of compounds 5a–5s.

Comp.	C. albicans	C. glabrata	C. krusei	C. parapsilosis
5a	12.5	6.25	6.25	12.5
5b	6.25	3.12	6.25	6.25
5c	12.5	6.25	6.25	12.5
5d	6.25	12.5	6.25	6.25
5e	12.5	6.25	12.5	12.5
5f	6.25	3.12	3.12	6.25
5g	3.12	6.25	6.25	6.25
5h	12.5	6.25	12.5	6.25
5i	0.78	1.56	1.56	0.78
5j	12.5	6.25	12.5	12.5
5k	12.5	6.25	12.5	12.5
5l	6.25	12.5	6.25	12.5
5m	3.12	3.12	3.12	6.25
5n	3.12	3.12	1.56	3.12
5o	3.12	3.12	6.25	6.25
5p	12.5	12.5	6.25	6.25
5r	6.25	3.12	3.12	3.12
5s	0.78	1.56	1.56	0.78
Ketoconazole	0.78	1.56	1.56	1.56
Fluconazole	0.78	1.56	1.56	0.78