A Simple and Improved HPLC-PDA Method for Simultaneous Estimation of Fexofenadine and Pseudoephedrine in Extended Release Tablets by Response Surface Methodology

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td class="align_left">Degradation reaction</td><td class="align_left">Typical conditions</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td class="align_left">Thermal degradation</td><td class="align_left">Heated at 105°C for three hours</td></tr><tr><td class="align_left">Acid hydrolysis</td><td class="align_left">Treated with 1 N HCl up to 24 hours</td></tr><tr><td class="align_left">Base hydrolysis</td><td class="align_left">Treated with 1 N NaOH up to 24 hours</td></tr><tr><td class="align_left">Oxidation</td><td class="align_left">Treated with 10% H<sub>2</sub>O<sub>2</sub> solution up to 24 hours</td></tr><tr><td class="align_left">Reduction</td><td class="align_left">Treated with 10% Na bisulfite solution up to 24 hours</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Types of degradation reactions and conditions.

Journal of Chemistry

tab1

Table 1

Table 1: A Simple and Improved HPLC-PDA Method for Simultaneous Estimation of Fexofenadine and Pseudoephedrine in Extended Release Tablets by Response Surface Methodology 

Table 1 | A Simple and Improved HPLC-PDA Method for Simultaneous Estimation of Fexofenadine and Pseudoephedrine in Extended Release Tablets by Response Surface Methodology 