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Journal of Chemistry
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2017
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Article
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Tab 3
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Research Article
A Simple and Improved HPLC-PDA Method for Simultaneous Estimation of Fexofenadine and Pseudoephedrine in Extended Release Tablets by Response Surface Methodology
Table 3
CCD design matrix with two independent variables and observed responses.
Std order
Run order
Blocks
MeOH (% V/V)
ACN (% V/V)
of PSU (min)
of FEX (min)
(%)
2
1
1
15
20
3.30
37.6
38.16
13
2
1
10
40
2.50
3.40
4.55
11
3
1
10
40
2.40
3.30
4.5
8
4
1
10
60
2.60
4.10
6.27
9
5
1
10
40
2.50
3.50
4.7
3
6
1
5
60
2.70
2.98
0.75
5
7
1
5
40
2.54
3.26
3.34
12
8
1
10
40
2.50
3.40
4.55
4
9
1
15
60
2.70
3.80
5.2
7
10
1
10
20
3.00
20.2
29.4
10
11
1
10
40
2.50
3.40
4.55
6
12
1
15
40
2.70
4.50
8.57
1
13
1
5
20
3.10
35.0
36.25