A Simple and Improved HPLC-PDA Method for Simultaneous Estimation of Fexofenadine and Pseudoephedrine in Extended Release Tablets by Response Surface Methodology
Table 6
Summary of precision.
Run order
PSU
FEX
50%
100%
150%
50%
100%
150%
HPLC-1, day 1
100.05
99.98
100.02
99.99
99.98
99.98
HPLC-1, day 2
99.99
99.92
100.07
99.99
100.01
100.51
HPLC-2, day 1
99.94
100.10
100.56
99.98
100.10
99.97
HPLC-2, day 2
100.01
99.90
100.10
99.99
100.06
99.94
% RSD of total variation
0.0457
0.090
0.2500
0.005
0.0531
0.2735
% RSD of system
0.0777
0.0849
0.3807
0.0071
0.0849
0.0071
0.0141
0.0141
0.0211
0.0010
0.0354
0.4021
% RSD of inter assay precision
0.0424
0.0424
0.0353
0.00
0.0212
0.3738
0.0495
0.1414
0.3241
0.007
0.0283
0.0212
row for HPLC variation on day 1 and lower row for HPLC variation on day 2 row for interday variation on HPLC-1 and lower row for interday variation on HPLC-2.