CryoProtect: A Web Server for Classifying Antifreeze Proteins from Nonantifreeze Proteins

Table 1

Existing methods for predicting antifreezing protein.

Method	Classifier	Interpretable	Stand-alone program	Web server	Sequence feature	Year
AFP-Pred	RF	No	✓		PCP	2011
iAFP	SVM	Yes		✓	-peptide compositions	2011
AFP_PSSM	SVM	No		✓	PSSM	2012
AFP-PseAAC	SVM	No	✓		PseACC	2014
TargetFreeze	SVM	No		✓	AAC, PseAAC and PsePSSM	2015
AFP-ensemble	RF	No		✓	AAC, DPC, PCP, PSSM, disorder information, and functional domain	2015
CryoProtect	RF	Yes		✓	AAC and DPC	This study

DT: decision tree, RF: random forest, SVM: support vector machine, AAC: amino composition, DPC: dipeptide acid composition, PCP: physicochemical properties, PSSM: position specific scoring matrix profiles, PseACC: pseudo amino acid composition, and PsePSSM: pseudo position-specific scoring matrix.
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