Synthesis and Evaluation of N-[1-(((3,4-Diphenylthiazol-2(3H)-ylidene)amino)methyl)cyclopentyl]acetamide Derivatives for the Treatment of Diseases Belonging to MAOs

<div>(a) Lineweaver–Burk plots for the inhibition of hMAO-B by compound 4b. [S], substrate concentration (μM); V, reaction velocity (nmol/min/mg protein). Inhibitor concentrations are shown at the left. Vmax values from 2xIC50 to control: 172.565, 243.902, 277.778, and 525.120 (nmol/min/mg protein). Km value of the noncompetitive inhibition: 0.443 ± 0.018 (µM). (b) Secondary plot for calculation of steady-state inhibition constant (Ki) of compound 4b. Ki was calculated as 0.346 μM.</div>

Journal of Chemistry

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Figure 3

Figure 3: Synthesis and Evaluation of N-[1-(((3,4-Diphenylthiazol-2(3H)-ylidene)amino)methyl)cyclopentyl]acetamide Derivatives for the Treatment of Diseases Belonging to MAOs

Figure 3 | Synthesis and Evaluation of N-[1-(((3,4-Diphenylthiazol-2(3H)-ylidene)amino)methyl)cyclopentyl]acetamide Derivatives for the Treatment of Diseases Belonging to MAOs 