Journal of Chemistry / 2018 / Article / Tab 2

Research Article

Synthesis and Antifungal Activity of β-Hydroxysulfides of 1,3-Dioxepane Series

Table 2

Minimum inhibitory concentrations (μg/ml) of the synthesized compounds against the studied fungal strains.

CompoundCandida albicansAspergillus fumigatusEpidermophyton floccosumMucor pusilosIC50 (µg/ml), human adipose tissue fibroblasts

3-SS120250250120171.6 ± 5.8
3-RR25050050025081.9 ± 2.2
3250500500250n/a
21>500>500>500>500n/a
2260120>50012092.2 ± 8.7
23>500>500>500>500n/a
24120120120120202.2 ± 10.1
25120120120120248.8 ± 12.5
26120120500250142.2 ± 12.9
27500500>500250135.5 ± 16.4
28>500>500>500>500n/a
30>500>500>500>500n/a
29-SS120120120120364.5 ± 23.6
29-RR250250250250500.6 ± 16.1
29250250250250390.1 ± 20.1
31-SS6060120120166.6 ± 12.8
31-RR60120120120141.4 ± 14.5
31120120120120143.3 ± 10.2
32-SS15151530156.0 ± 5.2
32-RR606060120178.3 ± 11.5
32606060120160.0 ± 4.1
33-SS1201201203099.8 ± 2.9
33-RR12025025012076.4 ± 4.8
3312025025012080.9 ± 1.7
Fluconazole120250250250>1500
Terbinafine1515155029.2 ± 3.4

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