Synthesis and Antifungal Activity of β-Hydroxysulfides of 1,3-Dioxepane Series

Table 2

Minimum inhibitory concentrations (μg/ml) of the synthesized compounds against the studied fungal strains.

Compound	Candida albicans	Aspergillus fumigatus	Epidermophyton floccosum	Mucor pusilos	IC50 (µg/ml), human adipose tissue fibroblasts
3-SS	120	250	250	120	171.6 ± 5.8
3-RR	250	500	500	250	81.9 ± 2.2
3	250	500	500	250	n/a
21	>500	>500	>500	>500	n/a
22	60	120	>500	120	92.2 ± 8.7
23	>500	>500	>500	>500	n/a
24	120	120	120	120	202.2 ± 10.1
25	120	120	120	120	248.8 ± 12.5
26	120	120	500	250	142.2 ± 12.9
27	500	500	>500	250	135.5 ± 16.4
28	>500	>500	>500	>500	n/a
30	>500	>500	>500	>500	n/a
29-SS	120	120	120	120	364.5 ± 23.6
29-RR	250	250	250	250	500.6 ± 16.1
29	250	250	250	250	390.1 ± 20.1
31-SS	60	60	120	120	166.6 ± 12.8
31-RR	60	120	120	120	141.4 ± 14.5
31	120	120	120	120	143.3 ± 10.2
32-SS	15	15	15	30	156.0 ± 5.2
32-RR	60	60	60	120	178.3 ± 11.5
32	60	60	60	120	160.0 ± 4.1
33-SS	120	120	120	30	99.8 ± 2.9
33-RR	120	250	250	120	76.4 ± 4.8
33	120	250	250	120	80.9 ± 1.7
Fluconazole	120	250	250	250	>1500
Terbinafine	15	15	15	50	29.2 ± 3.4