Centrosymmetric Binuclear Boron Compounds Derived from Dithiooxamides: Synthesis, Characterization, and Their Photophysical Properties

Ibarra-Rodríguez, Marisol; Muñoz-Flores, Blanca M.; Cerón, Jesús Lara; Santillán, Rosa; Ochoa, María E.; Waksman, Noemí; Jiménez-Pérez, Víctor M.

doi:https://doi.org/10.1155/2018/4295970

Journal of Chemistry

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Abstract Introduction Results and Discussion Conclusions Data Availability Conflicts of Interest Acknowledgments Supplementary Materials References Copyright Related Articles

Research Article | Open Access

Volume 2018 | Article ID 4295970 | https://doi.org/10.1155/2018/4295970

Centrosymmetric Binuclear Boron Compounds Derived from Dithiooxamides: Synthesis, Characterization, and Their Photophysical Properties

Marisol Ibarra-Rodríguez,¹Blanca M. Muñoz-Flores,¹Jesús Lara Cerón,¹Rosa Santillán,²María E. Ochoa,²Noemí Waksman,³and Víctor M. Jiménez-Pérez¹

Academic Editor: Esteban P. Urriolabeitia

Received02 May 2018

Revised26 Jun 2018

Accepted29 Jul 2018

Published04 Oct 2018

Abstract

In this paper, we report the synthesis and characterization of new boron compounds derived from dithiooxamides. The compounds were characterized by NMR (¹H and ¹³C), UV-vis, fluorescence spectroscopy, and high resolution mass spectrometry. The crystal structure of the mononuclear boron compound was determined by single-crystal X-ray diffraction analysis. The photophysical properties of the boron compounds were investigated, and we found moderate fluorescence emission (compound 2 Φ_F: 4.07% and compound 4 Φ_F: 2.89%). We also observed that the mononuclear complex presented greater stability. Compound 4 showed interesting luminescent properties; in solid state, it exhibited an increase in fluorescence by mechanostimuli by changing to a bright red color, and also in solution, it showed a decrease in fluorescence intensity when oxygen and air were supplied to the solution.

1. Introduction

Boron compounds are important in biological systems, and they result from the interaction with hydroxyl and amine groups [1]. Boron has a high affinity for oxygen-forming borates that are involved in enzyme inhibition. The isoelectronic nature of C=C and B-N bonding increases the use of boron in organic synthesis [2]. Boron compounds are widely studied due to their various applications such as luminescent materials [3, 4], lasers [5–10], OLEDs [11–13], materials for nonlinear optics [14],and chemical materials used in fluorescent tests [15, 16], among others. The development of ladder-type π-conjugated molecules with fully ring-fused structures gives rise to a set of desired properties such as intense luminescence, good thermal stability, and high carrier mobility. These properties are important in terms of their applications in optoelectronics, organic field-effect transistors, and lasers [17–19]. Representative elements have been introduced to the π-conjugated skeleton to modulate the electronic structures and different properties like optical properties [20–26]. Some compounds have been reported with π-conjugated diboron ladders. Zhang and coworkers reported a series of ladder-type π-conjugated diboron complexes I-IV with high thermal stabilities (Figure 1) [27]. The same research group synthesized four novel diboron-containing π-conjugated ladders (V-VIII); skeletons were modified by introducing electron-withdrawing and electron-donating groups into different sites of the backbones. These materials present good thermal stability, high fluorescence quantum yields, and strong electron affinity [28]. Recently, Jacquemin and coworkers reported first-principle simulations of the excited states’ properties of a large series of ladder-type π-conjugated organic molecules containing heteroatoms (Si, S, B, O, and N). They observed the phenyl rings that bonded to the boron atom do not play any role in the optical transition in compounds with similar core in this report [29]. Another research group has studied diboron BN-heterocycles; they suggested that the location of BN units, the steric congestion, and the linker unit within the π-conjugated backbone can greatly affect the electronic structure of these molecules as well as their photophysical/photochemical properties [30]. It is therefore important to study the properties and characteristics of new compounds and to understand the impact when modifying the structures. Fluorescent sensors have received attention because they have advantages in terms of sensitivity, selectivity, and the easy detection of the fluorescence changes of the systems [31]. Due to this, we are interested in the synthesis of new materials with the ability to sense different stimuli. In the present work, we reported the synthesis and characterization of two new boron compounds derived from dithiooxamides. They present greater stability in the solid state than in solution; however compound 2 was unstable in solution, obtaining an X-ray structure for a mononuclear species.

2. Experimental Methods

2.1. Material and Equipment

All starting materials were purchased from the Aldrich Chemical Company. Solvents were used without further purification. Melting points were performed on an Electrothermal Mel-Temp apparatus and were uncorrected. A high-resolution mass spectrum was obtained by LC/MSD TOF, on an Agilent Technologies instrument, with APCI as the ionization source. UV-vis spectra were obtained with a PerkinElmer Lambda 356 UV/VIS spectrophotometer, and emission measurements were performed on a Fluorolog-3 spectrofluorometer. ¹H and ¹³C spectra were recorded on a Bruker avance DPX 400. Chemical shifts (ppm) were relative to (CH₃)₄Si for ¹H and ¹³C.

2.2. Crystal Structure Determination

The crystal data of 2a were recorded on an Enraf-Nonius Kappa-CCD (λ MoKa = 0.71073 Å, graphite monochromator, T = 293 K-CCD rotating images scan mode). The crystal was mounted on a Lindeman tube. The structures were solved by direct methods using SHELXS-97 [32] and refined against F² on all data by full-matrix least-squares with SHELXL-97 [33]. All of the software manipulations were done under the WIN-GX environment program set [34]. All heavier atoms were found by Fourier map difference and refined anisotropically. Some hydrogen atoms were found by Fourier map differences and refined isotropically. The remaining hydrogen atoms were geometrically modelled and are not refined. Crystallographic data for the structures reported in this paper have been deposited in the Cambridge Crystallographic Data Centre: CCDC 1817739 for 2a.

2.3. Synthesis of 6,6′-(Thiazolo[5,4-d]thiazole-2,5-diyl)bis(2,4-di-tert-butylphenol) (1)

A solution of ethanebis(thioamide) 0.24 g (2 mmol) and 3,5-di-tert-butyl-2-hydroxybenzaldehyde 0.936 g (4 mmol) in 4 ml of DMF were heated under reflux for 24 h. The reaction mixture slowly cooled to room temperature; the precipitated solid was filtered and washed with methanol and acetone, giving a yellow solid (0.13 g-12% yield). The compound was soluble in THF. M. P.: 364°C. ¹H NMR (400 MHz, CDCl₃, 298 K) δ = 1.30 (s, 18H, t-Bu-6), 1.42 (s, 18H, t-Bu-8), 7.37 [d, 2H, H7], 7.39 (d, 2H, H9), and 11.83 (s, 2H, OH). ¹³C NMR (100 MHz, CDCl₃, 298 K) δ = 170.99 (C3), 152.99 (C5), 140.59 (C8), 137.25 (C6), 126.9 (C7, C9), 119.86 (C4), 28.47 (CH₃, t-Bu-6), 30.40 (CH₃, tBu-8), 33.3 (C, t-Bu-6), 34.36 (C, t-Bu-8). APCI-TOF-M.S. in positive ion mode calc. for [(C₃₂H₄₂N₂O₂S₂ + H)⁺]: 551.276049 u.m.a; Exp.: 551.275297.

2.4. Synthesis of 2,5-Bis(3,5-di-tert-butyl-2-((difluoroboryl)oxy)phenyl)thiazolo[5,4-d]thiazole (2)

A solution of 6,6′-(thiazolo[5,4-d]thiazole-2,5-diyl)bis(2,4-di-tert-butylphenol) 0.27 g (0.5 mmol) in 30 ml of THF and 1 ml of Et₂O·BF₃ was added and heated under reflux for 24 h. The reaction mixture slowly cooled to room temperature; the precipitated solid was filtered and washed with hexane, giving a yellow solid (0.22 g, 68% yield). The compound was soluble in THF. M. P.: 354–358°C. APCI-TOF-M.S. in positive ion mode calc. for [(C₃₂H₄₀B₂F₄N₂O₂S₂-1F)⁺]: 627.26694 u.m.a; Exp.: 627.266647. UV-vis (THF): λ_abs/max 436 nm.

2.5. Synthesis of 1,1′-(Thiazolo[5,4-d]thiazole-2,5-diyl)bis(naphthalen-2-ol) (3)

A solution of ethanebis(thioamide) 0.24 g (2 mmol) and 2-hydroxy-1-naphthaldehyde 0.68 g (4 mmol) in 4 ml of DMF were heated under reflux for 24 h. The reaction mixture slowly cooled to room temperature; the precipitated solid was filtered and washed with methanol, giving a red solid (0.34 g–39.7% yield). The compound was soluble in THF. M. P.: 339°C. ¹H NMR (400 MHz, DMSO-d₆, 298 K) δ = 7.38 (m, 4H, H6 and H10), 7.56 (t, 2H, H11), 7.91 (d, 2H, H9), 8.02 (d, 2H, H7), 8.49 (d, 2H, H12), 11.08 (s, 2H, OH). ¹³C NMR (100 MHz, DMSO-d₆, 298 K) δ = 113.04 (C4), 118.58 (C6), 123.95 (C10), 124.71 (C12), 128.23 (C11), 128.83 (C9), 132.80 (C7), 150.53 (C8), 155.05 (C5), 164.39 (C3). COSY [δ_H/δ_C]: 8.48/7.53 (H12/H11), 7.94/7.40 (H9/H10), 7.35/8.01 (H6/H7). HETCOR [δ_H/δ_C]: 7.37/118.49 (H6/C6), 7.41/123.92 (H10/C10), 7.53/128.19 (H11/C11), 7.92/128.70 (H9/C9), 8.00/132.88 (H7/C7), 8.48/124.69 (H12/C12). APCI-TOF-M.S. in positive ion mode calc. for [(C₂₄H₁₄N₂O₂S₂ + H)⁺]: 427.056947 u.m.a; Exp.: 427.05174.

2.6. Synthesis of 2,5-Bis(2-((difluoroboryl)oxy)naphthalen-1-yl)thiazolo[5,4-d]thiazole (4)

A solution of 1,1’-(thiazolo[5,4-d]thiazole-2,5-diyl)bis(naphthalen-2-ol) 0.27 g (0.5 mmol) in 30 ml of THF, 0.5 ml of Et₂O·BF₃ was added and were heated under reflux for 24 h. The reaction mixture slowly cooled to room temperature, the precipitated solid was filtered and washed with hexane; giving a red solid (0.19 g–72.79% yield). The compound was soluble in DMSO and THF. Yield of 0.19 g (72.79%). M. P.: 340°C. ¹H NMR (400 MHz, DMSO-d₆, 298 K) δ = 7.36 (m, 4H, H6 y H10), 7.54 (t, 2H, H11), 7.91 (d, 2H, H9), 7.99 (d, 2H, H7), 8.46 (d, 2H, H12). ¹³C NMR (100 MHz, DMSO-d₆, 298 K) δ = 112.96 (C4), 118.68 (C6), 123.89 (C10), 124.69 (C12), 128.21 (C11), 128.83 (C9), 132.19 (C7), 150.50 (C8), 155.13 (C5), 164.27 (C3). APCI-TOF-M.S. in positive ion mode calc. for [(C₂₄H₁₂B₂F₄N₂O₂S₂ + H)⁺]: 523.05407 u.m.a; Exp.: 523.421632. UV-vis (THF): λ_abs/max 428 nm.

2.7. Absorbance, Emission, and Luminescence Quantum Yields

UV-vis absorption spectra were measured on a PerkinElmer Lambda 365 spectrophotometer (a solution of 1 mg of the compound in 50 ml of solvent was prepared to determine the photophysical properties). Optical band gap (Eg) was determined from the intercept with the X axis of the tangent of the absorption spectrum drawn at absorbance of 0.1 [35]. The emission spectra have been recorded with a Fluorolog-3 spectrofluorometer, by exciting 10 nm below the longer wavelength absorption band. The molar extinction coefficients were calculated by the rearranged Beer–Lambert equation. Fluorescence quantum yields in solution were determined according to the procedure reported in literature [36, 37] and using quinine sulphate in H₂SO₄ 0.1 M as the standard (quinine sulphate λ_ext = 365 nm, Φ = 0.546 at room temperature) [38]. Three solutions with absorbance at the excitation wavelength lower than 0.1 were analyzed for each sample, and the quantum yield was averaged.

3. Results and Discussion

3.1. Synthesis

The ligands (1 and 3) were synthesized by condensation reactions of two equivalents of aldehyde with dithiooxamide in DMF under reflux for 24 h, according to the procedure previously reported [39, 40]. They were fully characterized by NMR (¹H and ¹³C), UV-vis, and mass spectrometry. The boron compounds were obtained in moderate yields (60–73%) by excess of Et₂O·BF₃ with the ligand under reflux in THF (Scheme 1). The resulting boron compounds are soluble in organic solvents compounds like THF and DMSO. The compounds were characterized by NMR (¹H and ¹³C), UV-vis, and mass spectrometry. The binuclear compound 2 is unstable in solution; we tried to obtain crystals suitable for X-ray diffraction but only crystallize the complex with one boron atom. The compound 2a crystallized by slow evaporation of THF/hexane (1/9). Suitable single crystals for X-ray analysis were obtained, and their ORTEP drawing of molecular structure is shown in Figure 2, while refinement parameters are available in Table 1.

The complex mononuclear 2a crystallized in the P2₍₁₎/n space group, the molecules were monoclinic and crystallized as a yellow prism. The crystal structure of 2a shows the one boron atom tetracoordinated with the ligand and the formation of four heterocycles of five and six members. Boron atoms adopt typical tetrahedral geometry, bond lengths B-O 1.418(5) Å and B-N 1.582(4) Å which are characteristic for tetracoordinated boron complex, compared with molecules reported[41, 42]. The crystal has a rigid π-conjugated between the rings 2, 3, and 4; however, the ring 5 is slightly outside of the plane of the thiazolothiazole skeleton caused by the steric effect of the substituent groups tert-butyl (Figure 3). The structure of the compound shows intermolecular interactions with S2 and the proton of the tert-butyl group of other molecules (2.923–2.995 Å) and parallelly displaced π–π interactions in the range from 3.905 to 4.111 Å. The intramolecular interactions shown are (H15-S2, 2.616), (N2-H of OH, 1.931), (H13 of tBu-O2, 2.336–2.278), (S1-H9, 2.741), and (H6 of tBu-O1, 2.380–2.314) Å (Figure 4).

Distances: B(1)-O(1) 1.418(5), O(1)-C(5) 1.341(4), B(1)-N(1) 1.582(4), B(1)-F(1) 1.324(6), B(1)-F(2) 1.370(5), N(1)-C(2) 1.375(4), C(2)-C(1) 1.356(4), C(1)-S(1) 1.726(4), S(1)-C(3) 1.731(3), C(1)-N(2) 1.361(4), and C(2)-S(2) 1.706(4) Å. Bond angles: F(1)-B(1)-N(1) 107.5(3), F(2)-B(1)-O(1) 110.1(3), F(2)-B(1)-N(1) 105.8(3), and N(1)-B(1)-O(1) 109.5(3)°.

3.2. Solution and Solid Structures

The spectra ¹H NMR for the ligands (1) and (3) show the downfield H-bonded phenolic proton at 11.83 and 11.08 ppm; when the boron atom is coordinated, this signal disappears and gives the first indication for the formation of compound 4. For complex 2, it was difficult to obtain a clean spectrum (Figure S4); it shows a mixture of signals between the ligand (1) and the possible compound 2, which gives us a possible indication of instability. The proposed structure of the boron compounds was confirmed by the mass spectra of boron derivatives; it showed the base peak corresponding to the molecular ion. The compound 2 shows a pattern of fragmentation due to the loss of one boron atom, obtaining the mononuclear compound (2a), followed by the loss of the second boron atom to obtain the ligand (Scheme 2). The isotopic distribution of parent ions in the spectra demonstrated the presence of two atoms of boron in the compound 2. The comparison of the predicted theoretical and experimental isotopic distributions of spectra for the compound is given in Figure 5. However, compound 4 does not present the fragmentation pattern corresponding to the species [M-BF2]; mainly, the ligand 3 fragment is observed (427.0677 m/z, 15.8%) (Figure S11).

3.3. Photophysical Characterization

The boron complexes are more emissive in the solid state than in solution. The UV-vis absorption and emission spectra of 2 and 4 in THF are shown in Figure 6 and the date in Table 2. Interestingly, the absorption spectra of complex 2 show an intense peak at 436 nm. The first absorptions are mostly attributed to the transitions from HOMO to LUMO, excited states involve possibly, mainly, the π-conjugated core [29]. The fluorescence spectra show maximum wavelengths between 465 and 509 nm for the compound 4 is more intense the emission. Compound 4 in solution (solvent THF) absorbs at 428 nm and emits at 509 nm; however in the solid state, it shows a clear red color, this difference in color is due to the fact that the compound in solution shows solvatochromism [43, 44]. The molar extinction coefficients (ε) of 2 and 4 were in the range of 51,000–56,000 M⁻¹·cm⁻¹. These values (ε) were higher than compounds with the same central cores reported recently [27, 30]. This behavior was possibly caused by the introduction of the fluorine atoms at the boron atom, similar to that reported by Matsui research group, they studied pyrazine-boron complexes with lower molar extinction coefficient values of (ε) lower when the boron atom presents substituents as in comparison with phenyl substituents [45]. However, the molar extinction coefficients (ε) of 2 and 4 were less than the binuclear species with different central cores [46]. The optical band gap values (2.75–2.80 eV) are slightly lower than similar compounds reported by Wang[30]. Fluorescence quantum yields in solution were determined according to the procedure reported in literature [36, 37], the boron compound exhibits lower values of fluorescence quantum yields of 2.9 to 4.1 than similar compounds reported as V-VIII [28], these low values of Φ_F can be due to the presence of electro-attractor atoms like fluorine and the promotion of nonradiative processes, and this behavior is similar to that reported by Kubota et al. [47]. Compound 2 shows a gradual decomposition in THF because it shows a slightly orange coloration, and after being exposed for one day at room temperature, the color of the solution changes to light yellow similar to the ligand; in addition, the absorption spectra of the solution at room temperature for one day is similar to the ligand (Figure S12).

(a)

(b)

The compounds present greater luminescence in the solid state and, as a result of this, they were ground for two minutes on a mortar. It is important to mention the boron compounds respond to mechanical stimuli such as friction observing. Compound 2 decreases the fluorescence intensity, similar to other molecules [48], while compound 4 slightly changes its coloration taking a bright red color (Figure 7); this may indicate a slight change in molecular arrangements by the application of the force [49].

It is important to study the ability to sense oxygen in cells because the deficit and excess oxygen is associated with health problems or diseases [50, 51]. Recently, a boron compound with the ability to sense oxygen at the cellular level has been reported [52]. Therefore, the effect of dissolved oxygen concentration on the emission intensity of compound 4 was evaluated in the degassed THF at 25 bar and with oxygen pressure for 60 s, followed by the addition of air for 60 s in two cycles (Figure 8). In the first cycle, the compound 4 shows a decrease in the fluorescence intensity, and in the second cycle a slight shift towards the blue is observed. When applying air in the second cycle, the compound decreases even more than the intensity of emission, the behavior similar to that reported in the literature, a consequence of paramagnetic behavior of oxygen molecules as well as generating the triplet state [53]. However, compound 4 in the presence of nitrogen for 60 seconds exhibited an increase in the emission, which may be a consequence of oxidation of the compound, and due to absorption spectra, the compound shows a hypsochromic shift.

4. Conclusions

In summary, we describe the synthesis, characterization in solution, and the solid state of two boron compounds, observing greater stability in the solid state; it was possible to obtain a structure of x-rays for a mononuclear compound. The effect of oxygen and dissolved air in compound 4 was studied observing a decrease in the intensity of emission upon addition of oxygen and increase in this emission when it is substituted by nitrogen, and in the solid state, this binuclear exhibited a slight mechanochromism in response to mechanical grinding; this behavior can be attributed to changes in the molecular arrangements.

Data Availability

The data used to support the findings of this study are available from the corresponding author upon request.

Conflicts of Interest

The authors declare that they have no conflicts of interest.

Acknowledgments

This research was financially supported by CONACYT (grant 240011). MIR thanks CONACYT for providing scholarship.

Supplementary Materials

The supplementary materials contain NMR spectra and mass spectra for 1–4 (Figures S1–S12), a graphical abstract (Figure S13), and X-ray crystallographic data of 2a (Figure S14). (Supplementary Materials)

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Copyright © 2018 Marisol Ibarra-Rodríguez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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