L-Proline-Catalyzed Synthesis of Phthalimide Derivatives and Evaluation of Their Antioxidant, Anti-Inflammatory, and Lipoxygenase Inhibition Activities

Table 2

Anti-inflammatory and antioxidant activities of products 1–7.

Compounds	Anti-inflammatory activity		Antioxidant activity
	% inhibition of albumin denaturation (conc. 1 mg/ml)	% membrane stabilization (conc. 1 mg/ml)	DPPH scavenging IC50 μM	H2O2 scavenging activity IC50 μM
1	74.42 ± 0.81	81.88 ± 0.0b	27.32 ± 0.03	84.00 ± 2.50
2	77.73 ± 0.35	83.91 ± 0.06	87.40 ± 0.15	61.00 ± 2.11
3	49.19 ± 1.11	55.95 ± 0.62	91.70 ± 0.05	78.00 ± 4.22
4	38.8 ± 0.62	54.48 ± 0.12	25.01 ± 0.98	61.00 ± 2.23
5	40.16 ± 0.31	67.78 ± 0.06	69.22 ± 0.12	88.50 ± 1.67
6	67.93 ± 0.75	71.29 ± 0.06	70.02 ± 0.11	79.00 ± 1.10
7	56.44 ± 0.66	61.73 ± 0.06	56.11 ± 0.1 1	71.65 ± 1.12
Aspirin	95.89 ± 0.06 (conc. 0.20 mg/ml)	85.92 ± 0.02 (conc. 0.20 mg/ml)	—	—
BHA	—	—	44.20 ± 0.06	—
Ascorbic acid	—	—	—	20.77 ± 1.64

Values are expressed as mean of triplate  ± SD.