Synthesis of Novel 1,2,4-Triazolyl Coumarin Derivatives as Potential Anticancer Agents

Table 1

Crystallization solvents, melting points, yield percentages, molecular formulae, and molecular weights of compounds 3, 4a–c, 5a–c, 6, and 7.

Comp. no.	Ar	Cryst. solvent	M.p. (°C)	Yield (%)	Mol formula (mol. wt.)
3	—	EtOH	226–229	80	C12H10N4O2S (274.30)
4a	4-OHC6H4	DMF/EtOH	248–250	60	C19H14N4O3S (378.40)
4b	4-MeOC6H4	DMF/EtOH	255–257	66	C20H16N4O3S (392.43)
4c	4-OH,3-MeOC6H3	DMF/EtOH	240–243	54	C20H16N4O4S (408.43)
5a	4-OHC6H4	DMF	271–273	74	C19H12N4O3S (376.39)
5b	4-MeOC6H4	DMF	282–284	62	C20H14N4O3S (390.42)
5c	4-OH,3-MeOC6H3	DMF	266–268	48	C20H14N4O4S (406.41)
6	—	Dioxan	236–239	78	C13H8N4O2S2 (316.36)
7	—	EtOH	244–246	85	C14H10N4O2S2 (330.38)
8a	4-OHC6H4	DMF/EtOH	273–275	64	C19H13N5O3S (391.40)
8b	4-ClC6H4	DMF/EtOH	264–267	75	C19H12ClN5O2S (409.85)
8c	4-H2NSO2C6H4	DMF/EtOH	283–285	55	C19H14N6O4S2 (454.48)