Protective Effect of Sika Deer (Cervus nippon) Velvet Antler Extract against Cisplatin-Induced Kidney and Liver Injury in a Prostate Cancer PC-3 Cell Xenograft Model

Figure 1

Scheme of the xenograft tumor model. Negative control (NC, phosphate-buffered saline (PBS), 200 µL), antler extract (AE 400 mg/kg), control (Con, PBS 200 µL + tumor cells), cisplatin (Cis 20 mg/kg + tumor cells), Cis + AE low dose (AEL, 200 mg/kg + Cis 20 mg/kg + tumor cells), and Cis + AE high dose (AEH, 400 mg/kg + Cis 20 mg/kg + tumor cells). From day 0, mice were injected thrice weekly, and CON, Cis, AEL, and AEH groups were left for 1 week. When the xenograft tumor volumes were approximately 100 mm³, mice were randomly assigned to four groups and treated accordingly.