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Journal of Chemistry
Volume 2018, Article ID 7232793, 9 pages
https://doi.org/10.1155/2018/7232793
Research Article

Drug Effect of Thulium(III)-Arsenazo III Complex on Herring Sperm DNA

Key Laboratory of Functional Small Organic Molecule, Ministry of Education, College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, China

Correspondence should be addressed to Hongbo Li; moc.621@211obgnohil and Suqin Wang; moc.361@361niqusgnaw

Received 22 April 2018; Revised 27 July 2018; Accepted 8 August 2018; Published 18 September 2018

Academic Editor: Marcelino Maneiro

Copyright © 2018 Hongbo Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

To assess the potential cytostatic properties of the thulium(III)-arsenazo III complex as a probe of rare earth complex antitumor drugs, the interaction information of the thulium(III)-arsenazo III complex with DNA was obtained by using spectroscopy, viscosity measurements, and voltammetric methods. The thermodynamic functions demonstrated that the binding constants of the thulium(III)-arsenazo III complex with DNA were Kθ298.15K = 4.84 × 106 L·mol−1 and Kθ308.15K = 4.48 × 106 L·mol−1, and the binding process was enthalpy driven. The increase in relative viscosity of DNA with the addition of the thulium(III)-arsenazo III complex and the results from Scatchard and voltammetric methods showed that the interaction mode between the thulium(III)-arsenazo III complex and DNA was groove binding along with weak intercalative binding.